5 Supplements to Improve Nocturia Symptoms

A 2020 study identified 5 ingredients for the treatment for Lower Urinary Track Symptoms (LUTS), including improving symptoms of nocturia (1)

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Table of Contents

The Short Answer.

  • Research suggests that taking a supplement containing the following ingredients 1 hour before bed can improve symptoms from Nocturia:

    • Beta-sitosterol
    • Pygeum africanum bark extract
    • Lycopene
    • Boron
    • Melatonin

  • If you have questions about side effects, talk to your healthcare provider.

What is Nocturia?

Nocturia is a condition that causes you to wake up during the night to urinate. Its cause can be sleep disorders, urinary tract disorders, aging, or simply high fluid intake before bed. Common treatment options for Nocturia include restricting fluid intake (especially 1-2 hours before bed) and supplements or medications that reduce overactive bladder symptoms.

How did this study work?

In 2020, researchers in Florida recruited 30 men to participate in a study for 60 days. Within 1 hour of going to bed each night, subjects took a supplement containing beta-sitosterol, pygeum africanum bark extract, lycopene, boron, and melatonin (1). 

The goal of the study was to measure the number of times that subjects woke up to urinate each night, and to measure their International Prostate Symptom Score (IPSS) over the course of treatment. IPSS measures outcomes like incomplete emptying of bladder, urinary frequency, weak stream, and other urinary health factors (1).

Key Findings: Improving Symptoms of Nocturia

Key Finding 1: taking a supplement with beta-sitosterol, pygeum, lycopene, boron, and melatonin 1 hour before bed reduced the number of times that subjects needed to go to the bathroom at night.
Key Finding 2: taking a supplement with beta-sitosterol, pygeum, lycopene, boron, and melatonin 1 hour before bed increased the self-reported life satisfaction of study participants.

Study Results: 5 scientifically backed supplements for improving nocturia symptoms

1. Beta-sitosterol for nocturia

Beta-sitosterol is a molecule found in fruits, vegetables, nuts, and seeds that is known as a plant sterol. Its chemical makeup is similar to cholesterol, which allows it to reduce cholesterol levels in your body by limiting cholesterol's ability to enter your body. Beta-sitosterol also helps to reduce swelling in prostate tissue and other tissues in your body (2). 

2. Pygeum africanum for nocturia

Pygeum is commonly used to treat inflammation, kidney disease, urinary tract disorders like nocturia, and prostate gland inflammation. Many studies have indicated that Pygeum is likely an effective treatment for benign prostatic hyperplasia (BPH) symptoms, which are typically similar to symptoms that are present in people suffering from nocturia (3).

3. Lycopene for nocturia

Lycopene is a carotenoid molecule made up of a 40-carbon long chain. Studies indicate that it is an antioxidant agent with potential anti-cancer properties and no known side effects with other medications. For example, a 2006 study from researchers at the Wake Forest University School of Medicine found Lycopene to be a safe and effective supplement for reducing one's risk of developing prostate cancer (4). 


4. Boron for nocturia

Boron is an element that's naturally found in many foods. It has been shown to improve inflammation by reducing several key biomarkers that are involved in the inflammation biomarkers in your body such as IL-6, TNF-a, and C-reactive protein. Boron helps regulate inflammation pathways that are associated with nocturia and other lower urinary tract symptoms. Finally, it regulates a growth factor in your body called IGF-1, which plays a role in benign prostatic hyperplasia (5).

5. Melatonin for nocturia

Melatonin is a key regulatory hormones that helps control your circadian rhythm. Many sleep disorders are caused by problems with melatonin regulation.

A cross-sectional cohort study of 861 men measured 6-sulfatoxymelatonin (6-SMT), the main metabolite of melatonin in the urine. Those with high levels of 6-SMT experienced significantly lower chances of nocturia symptoms. Thus, proper melatonin levels are an important factor in improving nocturia symptoms like having pee anxiety before bed or frequent urination (6).

Many studies have indicated that taking 2 mg per day of Melatonin supplements can improve sleep quality and reduce the number of times that you have to go to the bathroom after going to bed (7,8,9). 

This results in:

  • Less night-time trips to the bathroom 
  • Less dribbles of urine after urination

✔️ References
  1. Self-Assessed Benefits of a Prostate Health Formulation on Nocturia in Healthy Males With Mild Lower Urinary Tract Symptoms: An Open Label Study. doi: 10.1177/2164956120973639
  2. Beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. doi: 10.1046/j.1464-410x.1999.00026.x
  3. Pygeum africanum for benign prostatic hyperplasia. doi: 10.1002/14651858.CD001044
  4. Complementary and alternative medicine for advanced prostate cancer. doi: 10.1016/j.ucl.2005.12.007
  5. Nothing Boring About Boron. Integr Med (Encinitas). 2015 Aug; 14(4): 35–48
  6. Association between melatonin secretion and nocturia in elderly individuals: a cross-sectional study of the HEIJO-KYO cohort. doi: 10.1016/j.juro.2013.12.043
  7. How can we develop a more clinically useful and robust algorithm for diagnosing and treating nocturia? doi: 10.1002/nau.23569
  8. Association between melatonin secretion and nocturia in elderly individuals: a cross-sectional study of the HEIJO-KYO cohort. doi: 10.1016/j.juro.2013.12.043
  9. Effects of Melatonin and Rilmazafone on Nocturia in the Elderly. doi: 10.1177/147323000703500513